产品货号 :  mlR16767

英文名称 :  KLHL2

中文名称 :  Kelch样蛋白2抗体

别    名 :  ABP KELCH; Actin binding protein Mayven; Actin-binding protein Mayven; kelch; kelch like 2; Kelch like protein 2; Kelch-like protein 2; KLHL2; KLHL2_HUMAN; MAV; MAYVEN; OTTHUMP00000219997; OTTHUMP00000219998.  

研究领域 :  细胞生物  神经生物学  信号转导  结合蛋白  细胞骨架  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Rabbit,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  66kDa

细胞定位 :  细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human KLHL2:1-100/593

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍background:

KLHL2 is a 593 amino acid actin-binding protein. Highly expressed in brain, KLHL2 is thought to play a role in the organization of the actin cytoskeleton in brain cells. KLHL3 (kelch-like protein 3), is a 587 amino acid protein active in the protein ubiquitination pathway. KLHL3 is thought to be a substrate-specific adapter of an E3 ubiquitin-ligase complex that mediates the ubiquitination of target proteins, which leads to proteasomal degradation of the target protein. KLHL2 and KLHL3 proteins contain six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function.

Function:

May play a role in organizing the actin cytoskeleton of the brain cells.

Subcellular Location:

Cytoplasm > cytoskeleton.

Tissue Specificity:

Predominantly expressed in brain.

Similarity:

Contains 1 BTB (POZ) domain.

Contains 6 Kelch repeats.

SWISS:

O95198

Gene ID:

11275

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.