产品货号 :  mlR17192

英文名称 :  IZUMO1

中文名称 :  IZUMO1蛋白抗体

别    名 :  IZUM1_HUMAN; IZUMO; Izumo sperm egg fusion 1; Izumo sperm-egg fusion protein 1; Izumo1; MGC34799; OBF; Oocyte binding/fusion factor; Sperm specific protein izumo; Sperm-specific protein izumo.  

研究领域 :  细胞生物  发育生物学  细胞分化  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  39kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human IZUMO1:151-250/350 <Extracellular>

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]

Function:

Involved in the fertilization process. May be involved in the fusion of the sperm with the egg.

Subunit:

Monomer, homodimer and homooligomer. Interacts with IZUMO1R/JUNO (By similarity).

Subcellular Location:

Membrane.

Tissue Specificity:

Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction.

Post-translational modifications:

N-glycosylated. Glycosylation is not essential for fusion and for proper protein trafficking in sperm.

Phosphorylated.

Similarity:

Belongs to the Izumo family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

SWISS:

Q8IYV9

Gene ID:

284359

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.