产品货号 :  mlR21380

英文名称 :  TRPC6

中文名称 :  瞬时受体电位离子通道蛋白6抗体

别    名 :  MTRP6; Short transient receptor potential channel 6; si:rp71-1p14.9; Transient Receptor Potential Cation Channel Subfamily C Member 6; Transient receptor protein 6; TRP 6; TRP-6; TRP6; TRPC 6; TrpC6; TRPC6_HUMAN; TRRP6; bZ1P14.9; FLJ11098; FLJ14863; FSGS2.  

研究领域 :  细胞生物  免疫学  神经生物学  通道蛋白  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 Human, Mouse, Rat, Rabbit,

产品应用 :  WB=1:500-2000  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  106kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human TRPC6:831-931/931 <Cytoplasmic>

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq].

Subunit:

Interacts with MX1 and RNF24.

Subcellular Location:

Membrane; Multi-pass membrane protein.

Tissue Specificity:

Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.

Similarity:

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.

Contains 4 ANK repeats.

SWISS:

Q9Y210

Gene ID:

7225

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.