产品货号 :  mlR18181

英文名称 :  IOC4

中文名称 :  IOC4

别    名 :  Hypothetical 55.4 kDa protein in MCM1-NUP116 intergenic region; Ioc4p; IOC4_YEAST; YMR044W.  

研究领域 :  细胞生物  转录调节因子  表观遗传学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Saccharomyces cerevisiae

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  55kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from Saccharomyces cerevisiae IOC4:401-475/475

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  IOC4 is a member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing. IOC4 contains a PWWP motif.

Function:

Functions as component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing.

Subunit:

Component of the ISW1B complex, which at least consists of ISW1, IOC2 and IOC4.

Subcellular Location:

Nuclear

Gene ID:

855061

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.