产品货号 :  mlR23062

英文名称 :  Involucrin

中文名称 :  囊包蛋白/内披蛋白抗体

别    名 :  INVO_MOUSE; involucrin; ivl.  

研究领域 :  细胞生物  信号转导  细胞周期蛋白  细胞骨架  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应  :  Human, Mouse, Rat,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  64kDa

细胞定位 :  细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from mouse Involucrin:21-120/467

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008].

Function:

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

Subunit:

Directly or indirectly cross-linked to cornifelin (CNFN).

Subcellular Location:

Cytoplasm.

Tissue Specificity:

Keratinocytes of epidermis and other stratified squamous epithelia.

Post-translational modifications:

Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.

Similarity:

Belongs to the involucrin family.

SWISS:

P07476

Gene ID:

16447

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

套膜蛋白又称内披蛋白或囊包蛋白，与毛透明蛋白共同构成角质细胞包膜支架的蛋白质。在角质细胞分化时，首先出现在表皮棘层的上层细胞中的标志性蛋白质，该蛋白在角质细胞和其他复层扁平上皮合成的蛋白。最初存在于细胞质中，然后通过转谷氨酰胺酶的作用，转变为交联的膜蛋白。

产品图片