产品货号 : mlR1952
英文名称 : Cellubrevin
中文名称 : 囊泡相关膜蛋白3抗体
别 名 : Vesicle Associated Membrane Protein 3; VAMP-3; VAMP 3; VAMP3; CEB; Synaptobrevin 3; Synaptobrevin-3; MGC108618; Vamp3; D130027G05Rik; VAMP3_HUMAN; Vesicle-associated membrane protein 3.
研究领域 : 肿瘤 神经生物学 信号转导
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human,
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 11kDa
细胞定位 : 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human VAMP-3/Cellubrevin:2-60/100
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008].
Function:
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
Subcellular Location:
Membrane; Single-pass type IV membrane protein (Probable). Cell junction, synapse, synaptosome.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the synaptobrevin family.
Contains 1 v-SNARE coiled-coil homology domain.
SWISS:
Q15836
Gene ID:
9341
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
