产品货号 :  mlR19194

英文名称 :  NEK10

中文名称 :  丝氨酸/苏氨酸蛋白激酶Nek10抗体

别    名 :  FLJ32685; Never in mitosis A related kinase 10; NIMA (never in mitosis gene a) related kinase 10; NimA related protein kinase 10; Serine/threonine protein kinase Nek10. NEK10_HUMAN   

研究领域 :  细胞生物  信号转导  激酶和磷酸酶  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  133kDa

细胞定位 :  细胞核 细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human NEK10:51-150/1172

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  Nek10 is a 712 amino acid protein belonging to the NIMA subfamily of kinases and functions as a magnesium-dependent serine/threonine protein kinase. Kinases of the NIMA subfamily are typically involved in genotoxic stress response and DNA replication. Nek10 is expressed in brain and may contain a 14-3-3 interaction motif in its C-terminus. The gene encoding Nek10 has been localized to a region on chromosome 3 that may contribute to vulnerability to addictions. Due to alternative splicing events, three isoforms exist for Nek10.

Predicted molecular weight: 55 kDa for Isoform 5 (and 133 kDa for Isoform 1).

Function:

NEK10 belongs to the protein kinase superfamily; Ser/Thr protein kinase family; NIMA subfamily.

Similarity:

Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

Contains 1 ARM repeat.

Contains 1 protein kinase domain.

SWISS:

Q6ZWH5

Gene ID:

152110

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.