产品货号 :  mlR22457

英文名称 :  Cyclooxygenase 1

中文名称 :  前列腺素氧化环化酶1抗体

别    名 :  Cyclooxygenase-1; COX-1; COX 1; COX1; Cyclooxygenase1; Prostaglandin-endoperoxide synthase-1; prostaglandin-endoperoxide synthase 1; PTGS-1; Prostaglandin G/H synthase 1 precursor; prostaglandin G/H synthase 1 isoform 1 precursor; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; PGH1_HUMAN; PTGS1; Prostaglandin G/H synthase 1 precursor.  

研究领域 :  肿瘤  心血管  免疫学  信号转导  合成与降解  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  63kDa

细胞定位 :  细胞浆 细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human Cyclooxygenase 1 :101-200/599

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012].

Function:

May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.

Subunit:

Homodimer.

Subcellular Location:

Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.

Similarity:

Belongs to the prostaglandin G/H synthase family.

Contains 1 EGF-like domain.

SWISS:

Q63921

Gene ID:

5742

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成与降解（Synthesis and Degradation）

COX1 前列腺素氧化环化酶-是前列腺素合成的关键酶之一，为诱导性酶，他参与细胞对生长因子、肿瘤促进因子和细胞因子的反应，这些因子均能诱导COX1表达，它也参与前列腺素的合成。

产品图片