产品货号 : mlR3536
英文名称 : PPIG
中文名称 : 亲环蛋白（亲环素）PPIG抗体
别 名 : CARS cyclophilin; CARS Cyp; CARS-cyclophilin; CARS-Cyp; CASP 10; CASP10; Clk associating RS cyclophilin; Clk-associating RS-cyclophilin; Cyclophilin G; CyclophilinG; CYP; MGC133241; Peptidyl prolyl cis trans isomerase G; Peptidyl prolyl isomerase G; Peptidyl-prolyl cis-trans isomerase G; Peptidyl-prolyl isomerase G; Peptidylprolyl isomerase G (cyclophilin G); Peptidylprolyl isomerase G; PPIase G; Ppig; PPIG_HUMAN; Rotamase G; RotamaseG; SCAF10; SR cyclophilin; SR cyp; SR related CTD associated factor 10; SR-cyclophilin; SR-cyp; SRcyp.
研究领域 : 细胞生物 免疫学 染色质和核信号 信号转导 表观遗传学
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 89kDa
细胞定位 : 细胞核
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human PPIG:351-450/754
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : PPIG belongs to the the peptidyl-prolyl cis/trans isomerase protein family (PPIases). PPIases accelerate the folding of proteins. PPIG catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and is implicated in the folding, transport, and assembly of proteins. It is distributed in nuclear speckles, a nuclear compartment rich in splicing factors, and colocalizes with the splicing factors SC35 and pinin, suggesting a role in the regulation of pre-mRNA splicing.
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.
Subunit:
Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II.
Subcellular Location:
Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 1 PPIase cyclophilin-type domain.
SWISS:
Q13427
Gene ID:
9360
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肽基脯氨酰基顺反异构酶，广泛存在于各种组织和器官。根据对免疫抑制剂的敏感性，分属三个独立的家族：亲环蛋白PPIG、FK506结合蛋白和细蛋白。能够加速自身折叠和体内新生肽链折叠及变性蛋白质的体外折叠，主要分布于内质网。
