产品货号 :  mlR7019

英文名称 :  GBP5

中文名称 :  G蛋白结合蛋白5抗体

别   名 :  GBP 5; GBP-5; GBP TA antigen; GBP5; GBP-TA antigen; GBP5; GBP5_HUMAN; GTP binding protein 5; GTP-binding protein 5; Guanine nucleotide binding protein 5; Guanine nucleotide-binding protein 5; Guanylate binding protein 5; Guanylate-binding protein 5.  

研究领域 :  肿瘤  细胞生物  信号转导  转录调节因子  G蛋白信号  干扰素  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应  :  Human,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  66kDa

细胞定位 :  细胞浆 细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human GBP5/Guanylate binding protein 5:221-320/586

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍background:

GBP5 is a 586 amino acid protein that localizes to the cytoplasmic side of the cell membrane. Belonging to the interferon (IFN)-inducible guanylate-binding protein (GBP) family, GBP5 may be involved in the inflammatory response or with cell proliferation and is suggested to have possible cancer-related functions. The gene encoding GBP5 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.

Function:

Stimulates the NLRP3 inflammasome assembly upon bacterial challenge.

Subunit:

Homotetramer when interacting with NLRP3 (By similarity). Homodimerizes upon GTP-binding, dimerization is required for the second hydrolysis step from GDP to GMP. Can also heterodimerize with other members of the family. Homotetramer when interacting with NLRP3.

Subcellular Location:

Cytoplasm. Membrane; Lipid-anchor.

Similarity:

Belongs to the GBP family.

SWISS:

Q96PP8

Gene ID:

115362

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品图片 :