产品货号 :  mlR19142

英文名称 :  Myelin expression factor 2

中文名称 :  髓鞘表达因子2抗体

别    名 :  MYEF2; KIAA1341; MEF 2; MST156; MYEF2_HUMAN; MYEF 2; Myelin expression factor 2.  

研究领域 :  免疫学  转录调节因子  表观遗传学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  64kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human Myelin expression factor 2:1-100/600

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.

PubMed :  PubMed

产品介绍 :  Myelin basic protein (MBP) binds to negatively charged lipids on the cytosolic surface of oligodendrocyte membranes and is responsible for adhesion of these surfaces in multilayered Myelin sheaths. As a member of a larger family of proteins with many forms and post-translational modifications, MBP appears to have several other functions as a result of these modifications, including participating in the transmission of extracellular signals, as well as cell signaling. These modifications of MBP are dynamic during normal central nervous system (CNS) development and during Myelin degeneration in multiple sclerosis (MS). Regulation of the human MBP gene occurs at the MB1 regulatory motif located between nucleotides -14 to -50. The MB1 element contains binding sites for both the activator protein MEF-1/Pur?and the repressor protein MYEF2. MYEF2 is a nuclear protein whose expression is developmentally regulated in mouse brain with peak expression occurring at postnatal day 7. Four isoforms of MYEF2 exist due to alternative splicing events.

Function:

Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA.

Subunit:

Monomer (By similarity).

Subcellular Location:

Nuclear

Similarity:

Contains 3 RRM (RNA recognition motif) domains.

SWISS:

Q9P2K5

Gene ID:

50804

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.