产品货号 :  mlR2882

英文名称 :  LPA3

中文名称 :  溶血磷脂酸受体蛋白3/EDG7抗体

别    名 :  Calcium mobilizing lysophosphatidic acid receptor LP A3; Calcium mobilizing lysophosphatidic acid receptor LPA 3; Calcium mobilizing lysophosphatidic acid receptor LPA3; EDG 7; Endothelial cell differentiation gene 7; Endothelial differentiation lysophosphatidic acid G protein coupled receptor 7; FLJ98231; GPCR; HOFNH 30; HOFNH30; LP A3; LPA 3; LPA receptor 3; LPA receptor EDG 7; LPA receptor EDG7; LPA3; LPAR 3; LPAR3; Lysophosphatidic acid receptor 3; Lysophosphatidic acid receptor Edg 7; Lysophosphatidic acid receptor Edg7 (LPA receptor 3) (LPA3); Lysophosphatidic acid receptor Edg7; OTTHUMP00000011573; RP4 678I3; LPAR3_HUMAN; .  

研究领域 :  肿瘤  免疫学  信号转导  转录调节因子  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应  :  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

产品应用 :  WB=1:500-2000 ELISA=1:2000-5000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  39kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human EDG7/LPA3:101-200/353 <Cytoplasmic>

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍  :  EDG7 is a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. EDG7 has been reported in human prostate, as well as rodent brain, kidney, lung, placenta, prostate, and testis. ESTs have been isolated from a normal prostate library, as well as cancer libraries of the head/neck, ovary, and thyroid.

Function:

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

Subcellular Location:

Cell membrane; Multi-pass membrane protein.

Tissue Specificity:

Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.

Similarity:

Belongs to the G-protein coupled receptor 1 family.

SWISS:

Q9UBY5

Gene ID:

23566

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.