产品货号 :  mlR6159

英文名称 :  STARD8

中文名称 :  GTP酶激活因子STARD8抗体

别    名 :  Deleted in liver cancer 3; DLC3; StAR related lipid transfer protein 8; START domain containing protein 8; START GAP3; STAR8_HUMAN.  

研究领域 :  肿瘤  细胞生物  信号转导  转录调节因子  G蛋白偶联受体  细胞骨架  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  113kDa

细胞定位 :  细胞核 细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human STARD8:561-660/1023

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍background:

This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor.

Function:

Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1

Subunit:

Binds both the SH2 and PTB domains of TNS1.

Subcellular Location:

Binds both the SH2 and PTB domains of TNS1.

Tissue Specificity:

Widely expressed with highest levels in kidney, lung and placenta.

Similarity:

Contains 1 Rho-GAP domain.

Contains 1 START domain.

SWISS:

Q92502

Gene ID:

9754

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.