产品货号 :  mlR3854

英文名称 :  GREB1

中文名称 :  乳腺癌雌激素调控蛋白GREB1抗体

别    名 :  Gene regulated by estrogen in breast cancer protein; GREB 1; GREB-1; Protein GREB1; KIAA0575; GREB1_HUMAN.  

研究领域 :  肿瘤  细胞生物  免疫学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  216kDa

细胞定位 :  细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human GREB1:1851-1949/1949

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   GREB1 is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. GREB1 is expressed in proliferating prostate tissue & prostate cancer and is thought to act as a regulator of hormone-dependent cancer growth in breast and prostate cancers. Its promoter contains putative androgen receptor response elements. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Function:

May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.

Subcellular Location:

Membrane; Single-pass membrane protein (Potential).

Tissue Specificity:

Expressed in proliferating prostatic tissue and prostate cancer.

Similarity:

Belongs to the GREB1 family.

SWISS:

Q4ZG55

Gene ID:

9687

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GREB1是雌激素受体调节通路中早起反应基因，在乳腺癌、前列腺癌及前列腺增生中发挥着重要的调节作用。