产品货号 : mlR2692
英文名称 : Plexin A1
中文名称 : 神经丛蛋白A1抗体
别 名 : NOV; NOV/plexin A1 protein; NOVP; Plexin1; PlexinA1; PLXN1; PLXNA1; PLXNA1; protein; Semaphorin receptor NOV; PLXA1_HUMAN.
研究领域 : 心血管 细胞生物 免疫学 发育生物学 神经生物学 细胞膜受体
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea Pig,
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 206kDa
细胞定位 : 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human Plexin A1:901-1000/1896 <Extracellular>
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contain a semaphorin domain, multiple glycine rich motifs, and MET related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin mediated activation of Plexin A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin A1. The expression of Plexin A1, along with the co receptor Neuropilin 1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin A1 and Neuropilin 1, may have significant roles in axon regeneration after neuronal injury.
Function:
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Subunit:
Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2.
Subcellular Location:
Cell membrane (Probable); Single-pass type I membrane protein.
Tissue Specificity:
Detected in fetal brain, lung, liver and kidney.
Similarity:
Belongs to the plexin family.
Contains 4 IPT/TIG domains.
Contains 1 Sema domain.
SWISS:
Q9UIW2
Gene ID:
5361
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Plexins是一种单途径、具有多向潜在功能的跨膜蛋白，为Sema-phorins（神经信号蛋白）家族的受体,PlexinA1蛋白主要定位于细胞质和细胞膜，Semaphorins的很多重要的生理作用均是通过Plexins信号传导来发挥作用的。PlexinA1在神经系统形成、心血管生成、胚胎发生和免疫反应等方面发挥重要作用。
