产品货号 :  mlR1916

英文名称 :  RARRES1

中文名称 :  视黄酸受体应答蛋白1抗体

别    名 :  Retinoic acid receptor responder protein 1; RAR-responsive protein TIG1; Tazarotene-induced gene 1 protein; TIG1_HUMAN.  

研究领域 :  肿瘤  免疫学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应  :  Human, Mouse, Rat, Dog, Pig, Rabbit,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  33kDa

细胞定位 :  细胞膜 分泌型蛋白

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human RARRES1:201-294/294

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   RARRES1 (Retinoic acid receptor responder 1) is a retinoid-regulated gene whose expression is down-regulated through DNA hypermethylation. It was originally identified as a target gene that was induced by the synthetic retinoid tazarotene (AGN 190168). Its expression is upregulated by retinoic acid receptor-specific, but not by retinoid X receptor-specific retinoids. Although the function of RARRES1 is not entirely clear, it is thought to act as a tumor suppressor of a variety of human cancers since inactivation of RARRES1 is involved in the malignant progression of prostate cancer. It may also function as a cell adhesion molecule. Additionally, RARRES1 may also have protease inhibitor activity and inhibit the degradation of extracellular matrix.

Subcellular Location:

Membrane; Single-pass type II membrane protein (Potential).

Similarity:

Belongs to the protease inhibitor I47 (latexin) family.

SWISS:

P49788

Gene ID:

5918

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.