产品货号 :  mlR10956

英文名称 :  HDGF

中文名称 :  肝癌衍生生长因子/高迁移率族蛋白1样蛋白2抗体

别    名 :  HDGF; HDGF_HUMAN; Hepatoma derived growth factor; Hepatoma-derived growth factor; High mobility group protein 1 like 2; High mobility group protein 1-like 2; HMG-1L2; HMG1L2.  

研究领域 :  肿瘤  细胞生物  免疫学  肿瘤细胞生物标志物  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Pig, Cow, Guinea Pig,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  27kDa

细胞定位 :  细胞浆 细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human HDGF:81-180/240

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Function:

Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor.

Subunit:

Monomer, and domain-swapped homodimer.

Subcellular Location:

Cytoplasm. Nucleus.

Tissue Specificity:

Ubiquitous.

Post-translational modifications:

Sumoylated by SUMO1. Sumoylation prevents binding to chromatin.

Similarity:

Belongs to the HDGF family.

Contains 1 PWWP domain.

SWISS:

P51858

Gene ID:

3068

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.