产品货号 : mlR1663
英文名称 : THOC2
中文名称 : 转录因子THOC2抗体
别 名 : CXorf3; DJ506G2.1; hTREX120; RP5 1189B24.5; THO complex 2; THO complex subunit 2; THO2; THOC2; THOC2_HUMAN.
研究领域 : 肿瘤 细胞生物 转录调节因子 表观遗传学
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 175kDa
细胞定位 : 细胞核
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human THOC2:101-200/1593
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : THOC2 is a 1,478 amino acid nuclear protein that functions as a component of the heteromultimeric THO/TREX (transcription/export) complex, a multi-protein structure consisting of THOC1, THOC2, THOC3, BAT1 and ALY. The THO/TREX complex is recruited to transcribed genes and travels with RNA polymerase II (Pol II) during elongation, coupling elongating Pol II with RNA splicing and export factors. Defects in the protein components of the TREX structure can cause transcription impairment, mRNA export defects and transcription-associated recombination. THOC2, an important component of the TREX complex, exists as two isoforms that are produced by alternative splicing events.
Function:
Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex.The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4.
Subunit:
Component of the THO complex, which is composed of THOC1, THOC2, THOC5, THOC6 and THOC7. Together with THOC3, ALYREF/THOC4 and DDX39B, THO forms the transcription/export (TREX) complex. Interacts with THOC1.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the THOC2 family. Component of the THO complex, which is composed of THOC1, THOC2, THOC5, THOC6 and THOC7. Together with THOC3, ALYREF/THOC4 and DDX39B, THO forms the transcription/export (TREX) complex. Interacts with THOC1.
SWISS:
Q8NI27
Gene ID:
57187
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
THO复合体2亚基
产品图片
