产品货号 :  mlR19271

英文名称 :  NKX1-2

中文名称 :  转录因子相关蛋白NK2抗体

别    名 :  BB238F13.2; C10orf121; Homeobox protein SAX-1; NK1 homeobox 2; NK1 transcription factor related locus 2; NK1 transcription factor-related protein 2; NKX-1.1; NKX1-2; NKX12_HUMAN; Sax1; Sax1-like; Spinal cord axial homeobox gene 1.  

研究领域 :  细胞生物  神经生物学  转录调节因子  表观遗传学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human,

产品应用 :  IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  32kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human NKX1-2:1-100/310

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  NKX1-2 (NK1 Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is NKX1-1.

Function:

May function in cell specification, particularly in the CNS.

Subcellular Location:

Nucleus.

Tissue Specificity:

Expression detected in adult brain, testis and spleen. In the testis, expressed in the germ cells of the seminiferous epithelium, in elongating spermatids and in spermatozoa. Expressed throughout the brain with highest levels in regions of the cerebral cortex, hippocampus, diencephalon, pons, medulla and cerebellum. In the embryo, expressed in the developing posterior central nervous system. First seen in the ectoderm lateral to the primitive streak, later it encompasses the neural plate. Starting at day 9.5 pc, expressed in distinct areas of spinal cord, hindbrain, midbrain and forebrain.

Post-translational modifications:

Phosphorylated by HIPK2 in vitro.

Similarity:

Belongs to the NK-1 homeobox family.

Contains 1 homeobox DNA-binding domain.

SWISS:

Q9UD57

Gene ID:

390010

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.