产品货号 :  mlR1945

英文名称 :  WNK3

中文名称 :  丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体

别    名 :  Serine/threonine-protein kinase WNK3; WNK lysine deficient protein kinase 3; Protein kinase with no lysine 3; Protein kinase, lysine-deficient 3; Wnk3; RGD1563131; KIAA1566; PRKWNK 3; PRKWNK-3; PRKWNK3; Protein kinase lysine deficient 3; Protein kinase lysine-deficient 3; Serine/threonine-protein kinase WNK3; WNK 3; WNK3_HUMAN.  

研究领域 :  肿瘤  免疫学  染色质和核信号  信号转导  激酶和磷酸酶  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应  :  Human, Mouse, Rat, Cow, Rabbit,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  198kDa

细胞定位 :  细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human WNK3 protein:451-550/1800 <Cytoplasmic>

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍  :  WNK3 (WNK lysine deficient protein kinase 3) belongs to the serine/threonine protein kinase family. It lacks the almost invariant catalytic lysine in subdomain II, which is important for binding ATP in the catalytic site. A conserved lysine in subdomain I is thought to provide this function. WNK3 activates Na-(K)-Cl cotransporters by increasing their phosphorylation and appears to be a crucial component of the kinase/phosphatase signaling pathway that coordinately regulates the Cl– influx and efflux branches of the SLC12A cotransporter family.

Subunit:

Interacts with WNK1 and WNK4.

Subcellular Location:

Cytoplasm.

Tissue Specificity:

Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain-specific. Isoform 3 is kidney-specific.

Similarity:

BBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.

Contains 1 protein kinase domain.

SWISS:

Q9BYP7

Gene ID:

65267

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.