产品货号 :  mlR21062

英文名称 :  PPIP5K2/HISPPD1

中文名称 :  组氨酸酸性磷酸酶结构域蛋白1抗体

别    名 :  Diphosphoinositol pentakisphosphate kinase 2; HISPPD1; Histidine acid phosphatase domain containing 1; Histidine acid phosphatase domain containing protein 1; Histidine acid phosphatase domain-containing protein 1; hsVIP2; Inositol heptaphosphate kinase 2; Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2; InsP6 and PP IP5 kinase 2; InsP6 and PP-IP5 kinase 2; IP7K2; PP IP5 kinase 2; Ppip5k2; VIP1 homolog 2; VIP2; VIP2_HUMAN.  

研究领域 :  肿瘤  细胞生物  信号转导  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  138kDa

细胞定位 :  细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human PPIP5K2/HISPPD1:651-750/1243

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules. HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).[supplied by OMIM, Mar 2008]

Function:

Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP-InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2-InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer.

Subcellular Location:

Cytoplasm > cytosol.

Tissue Specificity:

Belongs to the histidine acid phosphatase family. VIP1 subfamily.

Similarity:

Belongs to the histidine acid phosphatase family. VIP1 subfamily.

SWISS:

O43314

Gene ID:

23262

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.