产品货号 :  mlR12650

英文名称 :  SNAP47

中文名称 :  突触相关蛋白SNAP47抗体

别    名 :  C1orf142; Chromosome 1 open reading frame 142; FLJ12517; HEL170; OTTHUMP00000035832; SNAP 47; SVAP1; Synaptosomal associated protein, 47kDa; t SNARE coiled coil homology domain containing protein C1orf142.  

研究领域 :  细胞生物  神经生物学  信号转导  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  52kDa

细胞定位 :  细胞浆 细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human SNAP47:281-380/464

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  SNAP47 belongs to the SVAP1 family. It contains two t-SNARE coiled-coil homology domains. SNAP47 has ubiquitous tissue distribution, with particularly high levels in nervous tissue. In neurons, SNAP 47 has been shown to have widespread distribution on intracellular membranes and is enriched in synaptic vesicle fractions. In vitro, SNAP 47 can substitute for SNAP-25 in SNARE complex formation, but not as efficiently.

Function:

Plays a role in intracellular membrane fusion.

Subunit:

Forms a complex containing SNAP47, VAMP2 and STX1A (By similarity). Associates with the BLOC-1 complex. Interacts with BLOC1S6.

Subcellular Location:

Endomembrane system. Cytoplasm; perinuclear region. Note: Appears to be exclusively membrane-bound.

Similarity:

Belongs to the SVAP1 family.

Contains 2 t-SNARE coiled-coil homology domains.

SWISS:

Q5SQN1

Gene ID:

116841

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.