产品货号 :  mlR7898

英文名称 :  PICK1

中文名称 :  蛋白激酶Cα相互作用蛋白1抗体

别  名 :  PICK 1; Pick1; PICK1_HUMAN; PRKCA binding protein; PRKCA-binding protein; Prkcabp; Protein interacting with C kinase 1; Protein interacting with PRKCA; Protein interacting with PRKCA 1; Protein kinase C alpha binding protein; Protein kinase C-alpha-binding protein; Protein that interacts with C kinase 1.  

研究领域 :  肿瘤  细胞生物  免疫学  神经生物学  信号转导  激酶和磷酸酶  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  46kDa

细胞定位 :  细胞浆 细胞膜

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human PICK1:201-300/415

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.

Function:

Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.

Subunit:

Monomer and homodimer.

Subcellular Location:

Cytoplasm, perinuclear region. Cell junction, synapse. Note=Also present at excitatory synapses.

Tissue Specificity:

Ubiquitous.

Post-translational modifications:

Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.

Similarity:

Contains 1 AH domain.

Contains 1 PDZ (DHR) domain.

SWISS:

Q9NRD5

Gene ID:

9463

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PICK1是衔接PKCα和膜上众多受体的关键蛋白之一，是细胞质中的膜结合蛋白,在蛋白质转运,以及细胞内信号转导过程中发挥重要作用；而在男性不育方面，PICK1蛋白也是促进精子顶体发育的关键蛋白，缺失PICK1蛋白将导致精子受破坏，失去活动能力和受精能力。

产品图片