产品货号 :  mlR16799

英文名称 :  KMT5C

中文名称 :  组蛋白赖氨酸N-甲基5C抗体

别    名 :  FLJ98627; Histone lysine N methyltransferase SUV420H2; KMT5C; Lysine N methyltransferase 5C; MGC2705; Su(var)4 20 homolog 2; SV422_HUMAN; Suppressor of variegation 4 20 homolog 2; Suv4 20h2; SUV420H2.  

产品类型 :  甲基化抗体

研究领域 :  细胞生物  表观遗传学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :   Human, Mouse, Rat, Dog, Cow, Horse, Sheep,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  52kDa

性  状 :  Lyophilized or Liquid

浓   度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human KMT5C:101-200/462

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍background:

SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]

Function:

KMT5C/SUV4-20h2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. KMT5C/SUV4-20h2 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions.

Subunit:

Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity). {ECO:0000250}.

Subcellular Location:

Nuclear.

Similarity:

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.

SWISS:

Q86Y97

Gene ID:

84787

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.