产品货号 :  mlR19991R

英文名称 :  PPP1R1C

中文名称 :  蛋白磷酸酶1调节亚基1c抗体

别    名 :  Inhibitor 5 of protein phosphatase 1; IPP5; PP1 inhibitor protein 5; Ppp1r1c; PPR1C_HUMAN; Protein phosphatase 1 regulatory subunit 1A; Protein phosphatase 1 regulatory subunit 1C; protein phosphatase 1, regulatory (inhibitor) subunit 1C.  

研究领域 :  细胞生物  神经生物学  信号转导  激酶和磷酸酶  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Dog, Rabbit,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  12kDa

细胞定位 :  细胞浆

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human PPP1R1C:1-100/567

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :  This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Function:

Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.

Subcellular Location:

Cytoplasm.

Tissue Specificity:

Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).

Post-translational modifications:

Phosphorylation at Ser-56 favors interaction with CALM1.

Isoform 1 is methylated by CARM1 in immature thymocytes.

Similarity:

Contains 1 R3H domain.

SWISS:

Q8WVI7

Gene ID:

151242

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.