产品货号 : mlR17483
英文名称 : SIAT4A
中文名称 : 唾液酸转移酶4A抗体
别 名 : 3-GalNAc-alpha-2; 3-sialyltransferase 1; 3-sialyltransferase; 3-ST 1; Alpha 2; Alpha 23 ST; Beta galactoside alpha 23 sialyltransferase; Beta-galactoside alpha-2; beta-galactoside alpha-2,3-sialyltransferase 1; CMP N acetylneuraminate beta galactosamide alpha 23 sialyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2; DKFZp666E036; DKFZp779K2051; FLJ36548; Gal beta 13 GalNAc alpha 23 sialyltransferase; Gal NAc6S; Gal-beta-1; Gal-NAc6S; MGC9183; OTTHUMP00000226912; OTTHUMP00000226913; SIA4A_HUMAN; Sialyltransferase 4A; SIAT4-A; SIAT4A; SIATFL; ST3Gal I; ST3GAL1; ST3GalA; ST3GalA.1; ST3GalI; ST3GalIA; ST3O.
研究领域 : 细胞生物 免疫学 神经生物学
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human,
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 39kDa
细胞定位 : 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human SIAT4A:151-250/340
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]
Function:
It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.
Subcellular Location:
Golgi apparatus > Golgi stack membrane. Secreted. Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Tissue Specificity:
Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas, spleen and placenta.
Post-translational modifications:
The soluble form derives from the membrane form by proteolytic processing.
Similarity:
Belongs to the glycosyltransferase 29 family.
SWISS:
Q11201
Gene ID:
6482
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
