产品货号 :  mlR18941

英文名称 :  MINA53

中文名称 :  组蛋白去甲基化酶赖氨酸MINA抗体

别    名 :  60S ribosomal protein L27a histidine hydroxylase; Bifunctional lysine specific demethylase and histidyl hydroxylase MINA; FLJ14393; Histone lysine demethylase MINA; MDIG; MINA; MINA_HUMAN; Mineral dust-induced gene protein; Myc induced nuclear antigen 53 kDa; MYC induced nuclear antigen; MYC-induced nuclear antigen; NO52; Nucleolar protein 52; Ribosomal oxygenase MINA; ROX.  

产品类型 :  甲基化抗体

研究领域 :  细胞生物  表观遗传学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  53kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human MINA53:251-350/465

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]

Function:

Involved in cellular proliferation. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.

Subcellular Location:

Nucleus. Nucleus; nucleolus.

Tissue Specificity:

Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.

Similarity:

Belongs to the MINA53/NO66 family.

Contains 1 JmjC domain.

SWISS:

Q8IUF8

Gene ID:

84864

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.