产品货号 :  mlR33063

英文名称 :  CDX2

中文名称 :  尾型同源盒转录因子2单克隆抗体

别    名 :  cau-dal-related homeobox transcription factor 2; Caudal type homeo box 2; Caudal type homeobox protein 2; caudal type homeobox transcription factor 2; CDX 2; CDX 3; CDX3; Homeobox protein CDX-2; Homeobox protein CDX2; CDX2_HUMAN.  

研究领域 :  肿瘤  发育生物学  染色质和核信号  转录调节因子  

抗体来源 :  Mouse

克隆类型 :  Monoclonal

克 隆 号 :  5G8

交叉反应  :  Human, Mouse, Rat,

产品应用 :  WB=1:500-1000 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  34kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human CDX2:

亚    型 :  IgG

纯化方法 :  affinity purified by Protein G

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. This gene is a member of the caudal-related homeobox transcription factor family that is expressed in the nuclei of intestinal epithelial cells.

CDX2 is also used in diagnostic surgical pathology as a marker for gastrointestinal differentiation, especially colorectal.

Function:

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

Subcellular Location:

Nucleus.

Post-translational modifications:

Phosphorylation of Ser-60 mediates the transactivation capacity.

Similarity:

Belongs to the Caudal homeobox family.

Contains 1 homeobox DNA-binding domain.

SWISS:

Q99626

Gene ID:

1045

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

核转录因子抗体

CDX2表达主要用于消化系统肿瘤及癌前病变的研究。用于与肿瘤的增值、分化、大小、临床分期及分化程度等关系方面的研究。CDX2是一种肠特异的转录因子，CDX2能够调节肠上皮细胞的增殖和分化，定位于肠上皮的绒毛和隐窝表面。据报道95%以上的浸润性结/直肠癌中均可检出CDX2阳性表达，也可在胃癌和卵巢黏液性腺癌中表达。