产品货号 :  mlR2510

英文名称 :  ZNF217

中文名称 :  锌指蛋白217抗体

别    名 :  zinc finger protein 217; ZABC 1; ZABC1; ZN 217; ZN217; ZNF 217; 4933431C08Rik; AW987152; Gm562; Zfp217; ZN217_HUMAN .  

研究领域 :  肿瘤  免疫学  染色质和核信号  信号转导  转录调节因子  结合蛋白  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应  :  Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,

产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  115kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human ZNF217:151-250/1061

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   ZNF217 (Zinc-finger protein 217) is a Kruppel-like zinc-finger protein which functions as a transcriptional repressor protein and forms a complex with a number of proteins including CoREST, BHC110/LSD1, HDAC2 and CtBP1. ZNF217 has been shown to repress E-cadherin promoter activity. ZNF217 is overexpressed in a number of cancers including breast and ovarian. ZNF217 and its associated proteins have been implicated in a novel pathway that is involved in cancer progression.

Function:

Binds to the promoters of target genes and functions as epressor. Promotes cell proliferation and antagonizes cell death. romotes phosphorylation of AKT1 at 'Ser-473'.

Subunit:

Component of a histone deacetylase complex that contains DAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone eacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, DM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and TF2I. Interacts with CTBP1 and CTBP2.

Subcellular Location:

Nucleus (Probable).

Similarity:

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 7 C2H2-type zinc fingers.

SWISS:

O75362

Gene ID:

7764

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.