产品货号 :  mlR0930

英文名称 :  phospho-heterochromatin protein 1 (pTyr41)

中文名称 :  异染色质蛋白1磷酸化抗体（果蝇）

别    名 :  Antigen p25; Cbx 5; Cbx5 antibody Chromobox homolog 5 (Drosophila HP1 alpha); Chromobox homolog 5 (HP1 alpha homolog Drosophila); Chromobox homolog 5; Chromobox protein homolog 5; Chromobox protein homologue 5 ; Heterochromatin protein 1 alpha; Heterochromatin protein 1; Heterochromatin protein 1 homolog alpha; HP 1; HP 1A; HP1 alpha homolog ; HP1A ; HP1Hs alpha; HP1Hs-alpha.   

产品类型 :  磷酸化抗体

研究领域 :  细胞生物  免疫学  染色质和核信号  昆虫  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应  :  Fruit Fly,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  23kDa

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated Synthesised phosphopeptide derived from Fruit Fly HP1 around the phosphorylation site of Tyr41:VE(p-Y)YL

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 :   HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin.

SWISS:

P05205

Gene ID:

N/A

Database links:

GenBank: ACI96782.1

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.