产品货号 :  mlR16924

英文名称 :  KCTD1

中文名称 :  钾离子通道多聚体结构域蛋白1抗体

别    名 :  BTB/POZ domain-containing protein KCTD1; C18orf5; Kctd1; KCTD1_HUMAN; Potassium channel tetramerisation domain containing 1; Potassium channel tetramerization domain-containing protein 1.  

研究领域 :  细胞生物  转录调节因子  表观遗传学  

抗体来源 :  Rabbit

克隆类型 :  Polyclonal

交叉反应 :  Human, Mouse, Rat, Rabbit,

产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量 :  29kDa

细胞定位 :  细胞核

性    状 :  Lyophilized or Liquid

浓    度 :  1mg/ml

免 疫 原 :  KLH conjugated synthetic peptide derived from human KCTD1:201-257/257

亚    型 :  IgG

纯化方法 :  affinity purified by Protein A

储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed :  PubMed

产品介绍 KCTD1 (potassium channel tetramerisation domain containing 1), also known as C18orf5, is a 257 amino acid protein that contains one BTB domain, suggesting an involvement in transcriptional control. The gene encoding KCTD1 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas.

Function:

May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent.

Subcellular Location:

Nucleus.

Tissue Specificity:

Expressed in mammary gland, kidney, brain and ovary.

Post-translational modifications:

Sumoylated.

Similarity:

Contains 1 BTB (POZ) domain.

SWISS:

Q719H9

Gene ID:

284252

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.